Abstract
In his former publications the author expressed a view that streptomycin intramuscularly administered is excreted in feces chiefly through the exposed blood vessels of the tuberculous intestinal ulcer.
The author carried out a further study on sensitivity and resistance of e. coli to streptomycin in the intestinal tuberculosis and has come to following conclusions.
1) when streptomycin was given intramuscularly to tuberculous patient the resistance of e. coli to streptomycin occurred almost immediately and it was retained in longer duration and in higher concentration than was found in healthy control group.
2) The Asaba's test gave a positive reaction to the intestinal tuberculosis group and negative to the control group. It also had a tendency to show negative reaction as improvement of clinical findings were noted by the strepomycin therapy.
3) The streptomycin excretion in feces was observed in 14/16 cases of the intestinal tuberculosis group. It showed a decrease or complete disappearance in proportion to improvement of clinical findings. There was no excretion of streptomycin in feces in the healthy control group. Thus it is considered that streptomycin is excreted chiefly through exposed blood vessels of the intestinal ulcer.
4) The searth for any influence of the intramuscular administration of streptomycin upon the growth of e. coli group revealed very little. Whereas a definite deminution of the number of colonies was noted within a few days after the beginning of streptomycin administration, it soon recovered its normal rate of growth. As to the correlation between bacterial types of the coli group and the nature and consistency of the feces, there was no remarkable findings.
5) It is considered following three tests are of important value in the diagnosis of the intestinal tuberculosis:
the Asaba's reaction, test for streptomycin excretion in feces and streptomycin resistance test for e. coli in feces.
