Abstract
In 8 autopsies of 21 pulmonary tuberculosis cases, renal calculi without clinical symptoms were found. The mechanism of the stone formation was examined pathologically. Results were as follows:
1) It is not clear whether there is any relation between stone formation and prolonged recumbency and skeletal tuberculosis.
2) It seems that isonicotinic acid hydrazide treatment has some effect on the calculi formation, for all cases which were treated with that drug had renal calculi.
3) The calculi had various kind of macroscopical appearances by each case in 4 cases, argyrophil fibrils and tubercle bacilli within the calculi were found.
4) Hyalin casts in tubular lumina and depositions of calcium in tubular epithelium, vascular endothelium and tuberculous tubercle of kidney were found in some cases. However, it seems that these are not the direct causes for the formation of calculi.
5) Tuberculous changes in the cortex of kidney were also observed.
6) Tuberculous and inflammatory changes in papilla andd mucosa of calyx, tissue desqua-mation in calyx and calcium deposition were found in most cases. These changes may be regarded as the primary factors in the formation of calculi.
