Abstract
Generally, 0.5% aqueous solution or 1.5% ointment of cortisone are customally used for the local application of cortisone against eye diseases, We conducted clinical study whether weaker solution of cortisone has any effects or not, In our experiments, 0.025% or 0.0125% of cortisone's aqueous solution and 0.01% cortisone ointment were administered 6 times daily or every one hour into conjunctival sacks or upon eye lids. Other symptomatic treatments were also given.
The prescriptions were as follows:
1) As for the eye-lotion, saline suspension of cortisone acetate Merck (24mg per cc) —0.05 or 0.1cc, methylcellulose —0.1g, sodium chloride—0.04g, sodium borate—0.2g and destilled water —10.0g.
2) As for the eye-ointment; Merck's ointment of cortisone acetate (1.5%)—0.1g, lanolin anhydrid—7.5g and vaselin alba—7.4g.
Although dramatic results, i. e., disappearance of all the symptoms within one or two days of administration were not obtained, subjective and objective symptoms were mitigated quickly and the periods of illness were shortened. Remarkable effects were found in phlyctenular conjunctivitis, phlyctenular keratitis, superficial punctate keratitis (initial stage), nummular keratitis, disk-shaped keratitis, rosacea keratitis, trachomatic pannus, lid der matitis, and tennonitis cases. Slight effects wete found in scleritis and scierosing keratitis cases. No effects were found in dendritic keratitis and syphylitic interstitial keratitis (end stage) cases.
