STUDIES ON THE ANTIMICROBIAL ACTIONS OF THE ANTITUBERCULOUS DRUGS IN VITRO

(3) THE INFLUENCES OF INAH, DSM, PAS, TBI UPON THE RATE OF GROWTH OF TUBERCLE BACILLI IN VITRO

Abstract

The effects of the antituberculous preparations upon the rate of growth of tubercle bacilli were observed, by various grades of concentrations of each drugs and by hours, i. e., 1, 2, 3, 6, 12 and 24 hours. The following results were obtained.
1) INAH, DSM, PAS, TB₁ had remarkable activities of inhibition of the growth of tubercle bacilli, by any grades of density tried. INAH showed the strongest effect, PAS cane in the 2nd order and DSM, TB₁ took the next places.
2) The inhibitory activities upon the rate of growth of tubercle bacilli within 6 hours were not remarkable, while by 12 hours the delay of the rate of growth of tubercle bacilli increased remarkably.