Abstract
In order to study the nature of anamie by ancylostomiasis the authors investigated morphological and physical changes of the blood and the bone-marrow from 19 patients with Ancylostoma dubini.
It was found that 79 per cents of the investigated cases showed 3 million level of blood cell counts. No evident relation was observed between the degree of anemia and number of expelled worms, although in many cases fewer worms were expelled when anemia was slight. The anemia was of hypochromic and microcytic nature. Number of reticulocytes in our cases was smaller than those in hemorrhagic anemia and larger than those in aregenerative anemia. There was no close connection between numbers of leukocytes and of expelled worms, nor any evident relation between acidophile percentage and expelled worms, nor between the anemia and occult blood reaction in stool, but there was some relation between occult blood reaction and expelled worms. Number of nucleated cells in bone-marrow was in normal range, and it seems noteworthy that when the anemia was of medium grade, nucleated cells tended to increase. The number of erythroblasts was also in the same relation as that of nucleated cells to the anemia. Basophilic erythroblasts in bone-marrow increased in proportion with anemia, whereas the polychromatophilic and normochromic increased when anemia was slight. Nucleus relatively matured in many cases. There was no tendency of increase of karyorrhexis subsequent to the exacerbation of anemia, but a picture of so-called maturearrest was observed. In leukocyte system, shifts to right or left wasnot distinct. No remarkable change was seen in thrombopoiesis. In bone-marrow tissues from severe anemia, slight edema and adiposis were observed. These findings were different from those in pernicious anemia by Rohr, which has mature-arrest. The etiology of ancylostomatic anemia can not be explained neither by hemorrhagic theory nor by hemolytic theory.
