Inteins in action

Francine B. Perler; Maurice W. Southworth; Lear Brace

doi:10.11490/isea.2005.0.124.0

International Symposium on Extremophiles and Their Applications 2005

DOI https://doi.org/10.11490/isea.2005.0.124.0

Conference information

Host: Japan Agency for Marine-Earth Science and Technology

Co-host: Toyo University, Japan Society for the Promotion of Science

Genetics and Protein Functions II

Inteins in action

*Francine B. Perler, Maurice W. Southworth, Lear Brace

Author information

Keywords: Intein, protein splicing, mechanism, gene conversion, homing endonuclease

CONFERENCE PROCEEDINGS FREE ACCESS

Pages 124-130

Details

Abstract

The mechanism of intein-mediated protein splicing was first described using an intein from a Pyrococcus species. Inteins are sporadically dispersed amongst the various phyla. Inteins are often encoded by mobile genetic elements that allow them to be horizontally transferred. Inteins naturally lacking the standard amino-terminal nucleophile can still splice by a slightly different mechanism. Understanding the mechanism of protein splicing has allowed scientists to harness inteins for numerous bioorganic chemistry and biotechnology application

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