ANALYSIS OF THE CURATIVE EFFECT OF GaAlAs DIODE LASER THERAPY IN FEMALE INFERTILITY

Abstract

Background and Aims: During the lifespan of the female, biochemical changes occur in the ovarian environment. These changes are brought about by numerous endogenous and exogenous factors, and can have a profound effect on ovarian oocyte quality. Oocytes of poor quality may be the cause of female infertility and are a major obstacle in successful assisted reproductive technologies (ART). We have previously reported on the efficacy of low reactive laser therapy (LLLT) using a GaAlAs diode laser device which emits laser light of 830 nm at an output of 60 mW to improve the poor quality of oocytes as an adjunctive treatment of refractory female infertility. The aim of this study is to assess the LLLT curative effect.
Subjects and Method: Eight hundred and fourteen female patients who presented at the Ohshiro clinic for treatment of infertility from July 1^st, 2000 till December, 2009 were enrolled in the analysis. We analyzed the therapeutic frequency and the therapeutic period (the number of menstrual cycles) between pregnant women and non-pregnant women. Results were expressed as means ± standard error of mean. The statistical difference was determined with the two-sided Student’s t-test and the Mann-Whitney’s U test. Differences with P ‹ 0.05 were considered significant.
Result: The mean therapeutic frequency and mean therapeutic period in the subjects who gave birth was 3.3 ±2.6 times a month and 5.2 ±6.1 months, respectively, which correspond to the whole oogenesis period.
Conclusion: We concluded that laser therapy once per week and a period of 5-6 menstrual cycles might be necessary to gain a good curative effect as the laser effect could last 1 week and the competence of oocytes depends on numerous processes taking place during the whole oogenesis period.