LASER THERAPY
Online ISSN : 1884-7269
Print ISSN : 0898-5901
ISSN-L : 0898-5901
Original Article
EFFICACY OF PHOTODYNAMIC THERAPY IN THE SHORT AND MEDIUM TERM IN THE TREATMENT OF ACTINIC KERATOSIS, BASAL CELL CARCINOMA, ACNE VULGARIS AND PHOTOAGING: RESULTS FROM FOUR CLINICAL TRIALS
Martínez-Carpio PAAlcolea-López JMVélez M
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JOURNAL FREE ACCESS

2012 Volume 21 Issue 3 Pages 199-208

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Abstract
Objective: To determine the clinical efficacy of methyl-aminolevulinate (MAL)-Photodynamic Therapy (PDT) in the treatment of actinic keratosis (AK), basal cell carcinoma (BCC), acne vulgaris (AV) and photoaging (PA), in the short and medium term.
Subjects and methods: Four separate prospective studies were designed on patients with AK (n=25), BCC (n=20), AV (n=20) and PA (n=25). Two PDT protocols were applied, and different clinical efficacy criteria were established, including lesion count and size. Two semi-quantitative and four analogue visual scales were completed for the evaluation of results according to the therapist, the patient and two independent experts.
Results: In the AK and BCC studies, full clinical remission was observed in 84.7% and 75.7% of lesions, respectively. In the AV study, the number of inflammatory and non-inflammatory lesions fell significantly (p<0.001, p<0.05). In the PA study a reduction in Dover scale scores (3.19 vs. 2.14, p<0.001) was proven. The percentages of satisfied or very satisfied patients were: AK=88%, BCC=90%, AV=89% and PA=80%. A year later, none of the AK or BCC lesions had reappeared, and the cases of AV and PA remained stable, with a tendency towards improvement.
Conclusion: the MAL-PDT procedures used produced efficacious, safe and satisfactory results in KA, BCC, AV and PA in the short and medium term.
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© 2012 Japan Medical Laser Laboratory
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