Abstract
Some biological properties of macrophages activated with Corynebacterium parvum, recombinant murine interferon-gamma (rMulFN-γ) and HeNe laser photodynamic therapy (PDT) were studied. Results obtained indicate the following: (i) macrophages activated with the three immunopotentiators have an intense phagocytic activity; (ii) the association of PDT-treated T and B peritoneal lymphocytes with macrophages increases their biological properties; (iii) the cytotoxic activity of photodynamically -activated macrophages (PD - AM Φ) varied between 42.8 and 59.4% of the normal function of the tumour target cells; and (iv) the three sets of macrophages exert cytostatic effects upon human and mouse leukaemia cells. In conclusion, macrophage immunopotentiation with photodynamic therapy has proved to be a useful method in cellular biological studies as well as for adoptive immunotherapy in various cancer forms.
