8-3 Observation of Cerebral Artery in Living Rat and Mouse Using Synchrotron Radiation : Response to Hypercapnia and Hemorrhagic Hypotension

Abstract

Microangiography with spatial resolution in the micrometer range was carried out to depict vascular responses of the cerebral artery and arterioles in rats and mice using a real-time imaging system and a third generation synchrotron radiation source at SPring-8. An X-ray direct-conversion type detector with 6-μm spatial resolution was developed for real-time biomedical imaging, hi imaging experiments, vasoconstriction and vasodilatation of small cerebral arteries were visualized in response to hypercapnia, hemorrhagic hypotension, and vasoactive agents after iodine contrast agent injection into the carotid artery.