1987 Volume 12 Issue 2 Pages 187-194
Effect of the 24-h fasting on the spontaneous motor activities: vertical (VMA), horizontal (HMA) and wheel-running motor activities (WRA), induced by a single administration of methamphetamine (2mg/kg, s.c.) and apomorphine (0.1mg/kg, s.c.), alone or in combination, to male ddY mice weighing 18-22g, was examined. The results are summarized as follows.
1)With fasting VMA increased markedly and HMA increased slightly, but no increase in WRA was noted.
2)When methamphetamine was administered to fasting mice, VMA increased significantly over that of mice which were fed. While HMA and WRA in fasting mice receiving methamphetamine showed the same patterns as those in mice which were fed.
3)When apomorphine was administered to mice which were fed and fasted VMA, HMA and WRA decreased at an early stage of the experiment.
4)When methamphetamine and apomorphine, in combination, were administered to fasting mice, VMA showed biphasic patterns comprising a decrease and an increase, while HMA showed a decrease and WRA showed an increase.
These results suggest that fasting may modify the activity of the central dopaminergic function.
