1992 Volume 17 Issue 3 Pages 153-157
The effects of oral and subcutaneous administration of sodium fluoride (NaF) on the monoaminergic systems at several discrete brain regions of mice were examined. The mice were sacrificed 30 min after oral or subcutaneous administration of NaF (1㎎/kg). The levels of noradrenaline (NE), dopamine (DA), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the seven brain regions were measured by high-performance liquid chromatography with an electrochemical detector. In the noradrenergic system, oral NaF increased the NE level in the midbrain (MB) and the MHPG levels in the hypothalamus (Hyp), stratum (Str) and MB. In the dopaminergic system, oral NaF increased the DA levels in the Str and hippocampus (Hip), and the DOPAC levels in the Hyp and Str. In the serotonergic system, oral NaF increased the 5-HIAA levels in the Hyp, Str, Hip and MB. Subcutaneous NaF increased the MHPG and DOPAC levels in the Hyp and the MHPG, DA and DOPAC levels in the Str. These results suggest that oral administration of NaF affects the activities of the monoaminergic systems over a wide area of the mouse brain. The mechanism of these actions of NaF may include the peripheral action of NaF.
