Basic investigation of cisplatin-induced apoptosis of murine squamous cell carcinoma cells

Abstract

Recently, many studies have investigated the relevance of apoptosis in tumor inhibition and anticancer drugs. As a result, was demonstrated that apoptosis was induced by many anticancer drugs. Furthermore, differences in induction by cell type are reported. Various anticancer drugs are useful for squamous cell carcinoma in the oral region, but details in vivo have not been demonstrated. This study examined changes in apoptosis induction in murine squamous cell carcinoma cells. As a result, apoptosis was correlated with tumor inhibition by cisplatin in murine squamous cell carcinoma cells, and apoptosis induction increased in a dose-dependent manner. Furthermore, immunohistochemical analysis showed that the expression rate of P53 protein and Bcl-2 protein correlated with the apoptotic index. Bax protein exression appears, but no further change was observed.

In this study, it was confirmed that apoptosis was induced by cisplatin in squamous cell carcimoma cells, and it was indicated that P53 protein and Bcl-2 protein levels which correlated with induction.