2018 Volume 42 Issue 3 Pages 120-126
We report an extremely rare case of a granular cell tumor in the left side of the submandibular region. The patient was a 38-year-old woman who was referred to our clinic because of complaints about swelling in the left submandibular region. The lesion was elastic, hard, and mobile, and measured approximately 30mm in diameter during the first visit. No tenderness was present. We suspected that the lesion was a benign tumor. Through the use of an ultrasonogram, CT, and MRI, it is impossible to deny that a malignant tumor developed in the mandibular gland. The lesion was resected under general anesthesia. Histopathologically, it consisted of uniform cells that had eosinophilic granules in their cytoplasm. In immunohistochemistry, the granules of the cytoplasmshowed an immunoreaction to S-100 protein and neuron-specific enolase（NSE）. The positive rate of Ki-67 was less than 2%. There was no tissue from the submandibular gland, so a histopathological diagnosis of the granular cell tumor in the submandibular region was made. Post-operatively, there has been no evidence of recurrence for 2 years and 5 months.
