1980 Volume 5 Issue 3 Pages 179-185
The inhibitory effect of chlorpromazine (CPZ) on pilocarpine-induced salivary res-ponse in mice was examined to determine the effect of single and repeated administration of CPZ. The experiment was carried out by the method of Richter, using urethane anesthetized mice. Single administration of CPZ (2,4,8and 40mg/kg, s. c.) inhibited clearly pilocarpine (1.25 mg/kg, s. c.) -induced salivary response. However, this inhibitory effect of CPZ was remarkably weak in comparison with that of atropine and did not exceed 50 per cent even when 40 mg/kg of CPZ was administered. When a fixed dose of 40r 40 mg/kg of CPZ was administered once daily for 21 days, the effect of 4 mg/kg of CPZ on 7 th,14th and 21th days decreased as com・ pared with the level of the initial effect. On the other hand, the effect of 40 mg/kg of CPZ was constantly maintained the level of the initial effect for 21 days. These results show that CPZ can inhibit the salivary function of salivary glands in mice, and tolerance to CPZ develops when a small dose of CPZ is repeatedly administered.
