1983 Volume 8 Issue 3 Pages 113-124
The subsensitivity (Sub s.) of mouse salivary gland induced by the pharmacological denervation was studied applying the parameters, total amount of saliva and maximal salivary flow rate, on pilocarpine-induced salivation. Pilocarpine-induced salivation was measured by a modified Richter’s method.
The results obtained are summarized as follows:
1) The supersensitivity (Super s.) and Sub s. of mouse salivary gland were induced after the withdrawal of the chronic administration of atropine (0.008-5mg/kg/day for 7 days), chlorpromazine (4 and 40mg/kg/day for 7days), amitriptyline (2 and 12mg/kg/day for 7 days), and promethazine (1.25 and 10mg/kg/day for 7 days).
2) The induction of Sub s. of mouse salivary gland was confirmed by the shift of dose-response curves to right.
3) The Sub s. developed only after the induction of the Super s.
4) Duration of the Sub s. was dependent on the dosage of the drugs.
5) Factors, such as the decreased information capacity accompanied by decreased number of binding site in receptor site as well as increased dsappearance rate of chemical mediators from active site, were responsible on the development of Sub s.
The present results show that the Sub s. post denervation is induced on the salivary gland as well as the sweat gland by the pharmacological denervation procedure.
