1983 Volume 8 Issue 3 Pages 146-150
The antisialagogic effect of chlorpromazine (CPZ) on the salivation controlled by the adrenergic system was examined in mice treated with CPZ chronically. The measurement of phenylephrine (PHE, 20mg/kg, s. c.) -induced salivation in mice was carried out by the modified Richter’s method. CPZ (2 and 40mg/kg, s. c.) and phenoxybenzamine (PBZ, 0.05 and 2.5mg/kg, s. c.) were successively administered to mice once a day for 21 days. The results are summarized as follows. (1) CPZ and PBZ administered singly inhibited PHE-induced salivation dose-dependently. (2) The antisialagogic action of the these drugs did not change during the period of the chronic administration, except for that of a large amount of CPZ (40mg/kg/day×21 days). (3) The change of the antisialagogic action induced by CPZ on the chronic administration may be due to the development of the pharmacological denervation supersensitivity. (4) Thirst and dry mouth induced by clinical long term administration of CPZ may be mediated by not only parasympatholytic action but also sympatholytic action of CPZ.
