Abstract
Non-invasive ductal carcinoma（DCIS） with apocrine differentiation is a rare disease. Herein we report three cases of the disease. Case 1：A woman in her 60s was found to have microcalcifications and focal asymmetric density（FAD） in her right breast on mammography（MG）. Since ultrasonography（US） showed a hypoechoic area in the AC area in her right breast, we suspected DCIS, but core needle biopsy（CNB） was not sufficient to determine whether it was benign or malignant, so a wait-and-see approach was taken. As US after six months showed no change, additional CNB and surgery were conducted before a diagnosis of DCIS with apocrine differentiation was made. Case 2：A woman in her 80s was found to have FAD and grouped microcalcifications in her right breast and a mass and pleomorphic calcifications in her left breast on MG. US showed a hypoechoic area in the CDE area in the right breast and a hypoechoic mass in the left breast. CNB and surgery were conducted before the same diagnosis as the first case was made for the right breast lesion and invasive ductal carcinoma was diagnosed for the left breast mass. Case 3：A woman in her 50s was found to have a mass in her left breast by her previous doctor. At the first US and eight-month US, we suspected DCIS, but a total of three vacuum assisted biopsies and additional CNB did not provide sufficient information to determine whether it was benign or malignant. Based on the previous results, we inferred breast cancer and performed a probe lumpectomy, which led to the same diagnosis as the first case. Although preoperative histopathological diagnosis was difficult in all cases, multimodality evaluation helped us to consistently confirm malignancy.
