A bone is moving in a lively way dynamically

Abstract

Bone is continuously destroyed by osteoclasts and reformed by osteoblasts to maintain bone volume and calcium homeostasis throughout the lifespan. Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte/macrophage lineage cells. Osteoblasts are involved in osteoclastogenesis. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. The research of “mechanism of osteoblastmediated osteoclast differentiation” directly links elucidation for bone mineral balance (coupling of bone tissue). In this review, we summarize the coupling mechanism regulated by osteoblastderived osteoclast differentiation factor (RANKL) and osteoprotegerin (OPG) which is a soluble decoy receptor for RANKL.