In dental practice, we often encounter patients who present with difficulty in opening their mouths. Trismus not only interferes with dental treatment, but may also indicate a life-threatening and urgent general condition. Based on the etiology, trismus is classified into inflammatory, neoplastic, arthritic, traumatic, muscular, cicatricial, and neurological. Inflammatory trismus is the most common, followed by trismus due to TMJ disorders. In addition, there are various other potential causes; thus, it is necessary to diagnose and treat the cause accurately. If the results of the treatment for the initial diagnosis are not satisfactory, it is necessary to reassess the clinical symptoms and consider the possibility of a different disease. In order to provide safe and reliable dental treatment, it is necessary to diagnose the cause of the trismus and administer the appropriate treatment.