Application of gene therapy to oral dieases

Cancer, pain, dry mouth, dental caries, and periodontal diseases Application of gene therapy to oral dieases

Abstract

Gene therapy was born as a causal treatment for hereditary conditions and was a therapy to compensate for defective genes. Today, various clinical applications are being investigated based on the basic concepts of supplementation of normal genes, suppression of gene expression, and repair of abnormal genes. In recent years, applications to oral and maxillofacial diseases have been considered, and research is being conducted. The authors also conducted research on gene therapy for pain caused by oral cancer and dry mouth caused by Sjogren's syndrome, an autoimmune disease. It is expected for gene therapy to be applied to dental caries and periodontal diseases that are routinely diagnosed by general dentists.