2008 Volume 22 Issue 2 Pages 164-168
A 13-year-old junior high school student was diagnosed with a primary mediastinal mixed germ cell tumor extensively invading the right chest cavity. On further qenetic examination, it was revealed he was a Kleinfelter's syndrome. Curative surgery was achieved using a hemi-clamshell approach followed by chemotherapy. Postoperative histopathological examination revealed that the yolk-sac component was almost necrotic. It is important for therapy of non-seminoma germ cell tumor to obtain a histological diagnosis, and employ a combination of chemotherapy including cisplatine and curative surgery.