Primary nodular pulmonary amyloidosis: Report of a case

Abstract

A healthy 82-year-old man presented with a well-defined nodule approximately 10 mm in diameter on an X-ray photograph, which was found in the right upper lobe on CT scan. As a trans-bronchial lung biopsy failed to facilitate a diagnosis, the patient underwent apical segmentectomy of the right upper lobe. The nodule consisted of eosinophilic, amorphous material, which was stained with Congo red, and showed an apple-green color with polarized light. Partial loss of elastic fibers of an adjacent pulmonary artery with amyloid deposition was identified on microscopic examination. He showed no amyloidal deposition in any other organs, nor any diseases related to amyloidosis. We diagnosed this case as nodular pulmonary AL amyloidosis in the parenchyma of the lung.