Abstract
A 46-year-old male presented with a mediastinal tumor on routine chest radiography. Chest computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated an 82×35×80-mm right anterior mediastinal tumor. One and half months later, he consulted again with chest pain and shortness of breath. CT showed left pleural effusion and the growing size of the tumor. As the intraoperative diagnosis by video-assisted thoracoscopic biopsy revealed type B2 thymoma, thymo-thymectomy with partial resection of the pericardium was performed. As thymoma with chest pain and pleural effusion is very rare, we presented this case with a review of the literature.