Clinical analysis of relationship between lung cancer and collagen disease

Abstract

A total of 437 primary lung cancer patients underwent curative surgery from 2006 to 2010. Twenty-two patients (5.0%) had collagen disease. Sixteen (72.7%) patients had rheumatism, 3 (13.7%) patients had systemic sclerosis, 2 (9.1%) had systemic lupus erythematosus, and 1 (4.5%) had adult Still's disease. Sixteen (72.7%) patients were pathological stage IA, 4 (18.2%) were stage IB, and 2 (9.1%) were IIIA. Eighteen (81.8%) patients had adenocarcinoma, 2 (9.1%) had squamous cell carcinoma, 1 (4.5%) had large cell neuro-endocrine carcinoma, and 1 (4.5%) had pleomorphic carcinoma. Sixteen (72.7%) patients underwent lobectomy, 2 (9.1%) patients received segmentectomy, and 4 (18.2%) patients underwent partial resection. Only postoperative pneumothorax occurred after surgery as a complication, and there was no significant difference between patients with and without collagen disease (P=0.539). The only significant difference was in preoperative interstitial pneumonitis (P=0.001). Therefore, we were able to perform surgery with the careful observation of patients with collagen disease.