2015 Volume 29 Issue 1 Pages 56-61
A 62-year old woman underwent liver transplantation for hepatocellular carcinoma secondary to hepatitis C virus cirrhosis. Five years after the operation, chest computed tomography showed a small nodule in a right middle lobe of the lung, and she was followed up. Two years later, the nodule developed to 37 mm in diameter. Transbronchial lung biopsy of the tumor revealed lung adenocarcinoma. The clinical stage was estimated as IB (cT2aN0M0). After another 2 months, right middle lobectomy and systemic nodal dissection were performed. Pathologically, there was metastasis in the same lobe of the lung, and pleural lavage cytology was also positive. Therefore, the pathological stage was IIIA (pT3N2M0). Postoperative combination chemotherapy of Cisplatin and Vinorelbine was performed. However, one year after the initial operation, recurrence and metastasis occurred. After 4th-line chemotherapy, palliative care was chosen. The incidence of de novo malignancy after organ transplantation has been reported to be 3-4 times higher than that in the general population. Careful follow-up for early detection and treatment is important for transplant patients.
