2024 Volume 38 Issue 7 Pages 580-584
Nodular lymphoid hyperplasia (NLH), a rare disease, is classified as a reactive lymphoproliferative disease, making differentiation from malignancy challenging. In this study, we reviewed the clinical characteristics of NLH resection cases. Eight patients who underwent surgery between 2014 and 2022 and were diagnosed with NLH based on pathological findings were included in the study. The patient sample consisted of 4 men and 4 women, with a median age of 67 years (51-83 years). Four of the patients had a history of smoking and 3 had an autoimmune disease. Ground glass and solid nodules were observed on computed tomography in 4 men and 3 women, with a median tumor diameter of 15 mm (11-38 mm). In all cases, the preoperative diagnosis was primary lung cancer. Patients' background and imaging findings were similar to those in previous reports; however, a larger proportion of patients had a comorbid autoimmune disease. Consequently, preoperative diagnosis was difficult, and aggressive surgical biopsy was desirable for pulmonary nodules that presented with enlargement tendencies. Therefore, further case studies are warranted to determine the relationship between autoimmune disease and NLH.
