LAK activity of lymphnode cells after subcarinal injection of OK-432 in patients with lung cancer

Abstract

Subcarinal injection of 20KE of OK-432 for the lung cancer patients was performed with bronchofiberscope at 4-10 days before thoracotomy. 51Cr-release assay of resected lymphnode cells at operation was carried out with or without IL-2 stimulation.
Although LAK activity with IL-2 stimulation was not detected with or without OK-432 administration, stimulation of lymphnode cell activity was demonstrated when it was measured without IL-2 stimulation. Metastatic lymphnode cell activity was reduced, when it was measured with IL-2 stimulation.