Abstract
A series of 263 patients with surgically resected non-small cell lung cancer was analyzed retrospectively. The p53 expression was examined immunohistochemically with monoclonal antibody DO-1 in formalin-fixed, paraffin-embedded tissues. The growth fraction was determined by the labeling index of 1 for the proliferation-associated antigen Ki-67. Tumors with p53 expression had a higher growth fraction than did those without p53 expression (p<0.001). Stage I and II patients with p53 expression tended to have a lower 5-year survival rate. Stage III and IV patients with p53 expression had a significantly shorter 5-year survival than did those without p53 expression (p<0.01). These findings indicate that p53 expression may accelerate tumor cell proliferation and may be a poor prognostic factor in non-small cell lung cancer.
