The Journal of the Japanese Association for Chest Surgery
Online ISSN : 1881-4158
Print ISSN : 0919-0945
ISSN-L : 0919-0945
Relationship between expression of sialyl Lewis x antigen and clinicopathologial features and prognosis of stage I non small cell lung cancer
Takamitsu MaeharaYasufumi HayashiTakao MorohoshiKyota IijimaKatsuhiko MukaiTatsushi YamagataKazuhiro SakamotoNaoki IshiwaYutaka KumakiriHaruhiko IshiiToshio Imada
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1997 Volume 11 Issue 4 Pages 517-522

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Abstract
Immunohistochemical expression of sialyl-Lewis x carbohydrate antigen (sLex) was examined in relation to clinicopathological factors and prognosis in 66 patients with stage I non -small cell lung cancer, who underwent surgical resection. There were 36 adenocarcinoma, 24 squamous cell carcinoma, 3 large cell carcinoma and 3 adenosquamous cell carcinoma. A significant difference was detected in the expression of sLex between adenocarcinoma and squamous cell carcinoma.
The incidence of sLex positive was not related to the histological differentiation or vascular invasion, but tumor with strong expression of sLex showed high frequency of recurrence of distant organs. Though vascular invasion and the expression of sLex were not significant prognostic factors by univariate analysis, those who was both positive for vascular invasion and high eypression of sLex had a worse prognosis. It is concluded that combined vascular invasion with expression of sLex may be a useful predictor of survival.
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© The Japanese Association for Chest Surgery
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