1995 Volume 9 Issue 4 Pages 532-537
A 62-year-old man was admitted because of an abnormal shadow on a chest roentgenogram. Computed tomogram revealed an oval high density mass, 4.0 × 3.0 cm in size, in the peripheral portion of S10 of the right lung just beneath the pleura. The serum α-fetoprotein (AFP) was moderately elevated to 186 ng/ml, with affinity to concanavalin A of 12%. Other tumor markers, CEA, CA19-9, SCC antigen and HCG were within normal limits. The serum AFP level decreased rapidly after right lower lobectomy. The tumor was diagnosed as adenosquamous carcinoma, t2, nl, m0, stage II, and several cancer cells growing in an adenocarcinoma pattern were positive for AFP immunohistostaining. Forty-five literature cases plus present case of AFP-producing lung cancer were analyzed. There were 42 men and 4 women with a mean age of 67 years. The serum AFP level varied from 73 to 309, 530 ng/ml. The most common histologic diagnosis was adenocarcinoma (67%), especially poorly differentiated type. AFP-producing adenosquamous carcinoma of the lung is rare ; this report is considered to be the second in the literature.
