2009 Volume 29 Issue 3 Pages 427-435
(1)to devise an intensive liver support regimen, involving plasma exchange in combination with hemodiafiltration using “ high performance membranes ” with a large volume of bicarbonate buffers, which is able to keep patients alive in whom the state of liver failure is as severe as that of an ahepatic state.(2)to introduce antivirals including interferon and nucleoside analogues in combination with high dose of methyl prednisolone with tapering and gradual increase in the dose of cyclosporine for viral hepatitis, and a high dose of methyl prednisolone with tapering for autoimmune and drug — induced hepatitis for the prompt alleviation of underlying hepatitis.(3)to accurately predict the occurrence of coma during the stage of acute severe hepatitis, and block the development of fulminant hepatic failure. Those measures have significantly improved the prognosis of fulminant hepatic failure in Japan.
