A case of Thrombosis of the Superior Mesenteric Vein due to Protein C and S Deficiency Disease

Abstract

The case pertains to a woman in her seventies. She consulted a nearby doctor with the chief complaint of fever and abdominal pain and was diagnosed by careful examination as having thrombosis of the cranial mesenteric vein and referred to our hospital. CT revealed a thrombus in the superior mesenteric vein extending from the ileocolic vein to the section merging with the splenic vein. Moreover, edematous change and parenteral air were observed in the ileocecum, and gastrointestinal perforation at this site was suspected. From the above, the patient was diagnosed as having thrombosis of the superior mesenteric vein and gastrointestinal perforation, and an emergency operation was carried out. Penetration into the mesentery was observed from the ileocecal valve to the ileum on the approximately 3cm oral side. Mild edema was observed almost throughout the length of the ileum；however, the color was normal. Ileocecal resection and colostomy were carried out. Laboratory examination at admission to our hospital revealed decreased serum protein C and S levels. We report this case due to the rarity of thrombosis of the superior mesenteric vein associated with protein C and S deficiency disease.