Abstract
We retrospectively investigated 60 patients who were admitted to Showa University Hospital from November 2002 through September 2011 and performed continuous regional arterial infusion (CRAI) with protease inhibitor and antibiotics for severe acute pancreatitis (SAP) (median age, 53 years old; 47 male and 13 female patients). The median Japanese prognostic factor score was 4 points. 35 patients were Grade 2 and 25 were Grade 3 in enhanced CT Grading, and 86.7% had a pancreatic area that was not contrasted. We performed CRAI for SAP in 58 patients from the celiac artery and superior mesenteric artery, and in to 2 patients from the celiac artery. We started CRAI at the first hospital day, and performed it for 5 days (median). Abdominal pain disappeared at 5 hospital days (median), the late severe infectious complication rate was 16.1%, and the mortality rate was 8.3%. The severity of the pancreatitis and inflammation improved significantly following CRAI. A randomized controlled trial is necessary to prove the usefulness of CRAI for SAP.
