Abstract
We retrospectively investigated 104 patients who were admitted to Showa University Hospital from November 2002 through June 2012 and underwent continuous hemodiafiltration (CHDF) for severe acute pancreatitis (SAP) (median age, 56 years; 78 male and 26 female patients). The median Japanese prognostic factor score was 4 points. Three patients were consistent with Grade 1, 74 were Grade 2 and 27 were Grade 3 in enhanced CT Grading. We started CHDF from the second day of the acute pancreatitis, and performed hemodialysis for 5 days (median). Early organ dysfunction rate was 86.5% (renal dysfunction rate: 23.1%), and the mortality rate was 15.4%. Significant improvement in the severity of acute pancreatitis, inflammation and complications rate were achieved with CHDF. On the other hand, there was no significant difference between the mortality rate when CHDF was started before the second day and after the third day during acute pancreatitis. A randomized controlled trial is necessary to prove the usefulness of CHDF for SAP.
