Treatment Outcomes and Prognostic Factors in Patients with Obstructive Colorectal Cancer

Abstract

Purpose: We investigated the treatment outcomes in patients with obstructive colorectal cancer. Methods: We identified 462 patients with colorectal cancer pStage Ⅱ/Ⅲ at our hospital between January 2007 and December 2018; the patients were divided into two groups; the obstructive colorectal cancer (OCC) group (n＝91) and the non-obstructive colorectal cancer (NOCC) group (n＝371). The background characteristics and treatment outcomes of the two groups were compared retrospectively, and the prognostic factors in patients with OCC were explored. Results: The body mass index and serum albumin level were significantly lower, and the serum CEA level was significantly higher in the OCC group. The OCC group also showed significantly higher frequencies of pT4 and pN2/3 disease. There was no significant difference in the pStage Ⅱ/Ⅲ classification rate between the two groups. There were also no significant differences in the operation frequency of postoperative complications between the two groups. The 5-year relapse-free survival rate and overall survival rate were significantly lower in the OCC group. A multivariate analysis identified Alb ＜4.0 g/dL as an independent poor prognostic factor in patients with OCC. Conclusions: The OCC group had a poorer prognosis than the NOCC group. Hypoalbuminemia was an independent poor prognostic factor in patients with OCC.