Abstract
A 53-year-old woman was admitted to our hospital because of bloody stools on June, 2001. Colonoscopicfindings led to a diagnosis of ulcerative colitis, and the patient was treated with mesalazine andpredonine. Her condition worsened, and leukocytopheresis therapy was started. In addition, predonine andulinastatin were injected via the superior and inferior mesenteric arteries. Despite these treatments, theclinical symptoms became aggravated, and colonoscopic findings indicated a worsening of the ulcerativecolitis. On August, 2001, the patient underwent an emergency operation because a toxic megacolon wasdetected by plain abdominal X-ray and severe peritoneal signs were recognized. Intraoperatively, the wallof the entire large intestine was found to be very thin, and the cecum was perforated. The large intestinewas resected, and an ileostomy was performed. Endotoxin adsorption therapy was performed twice becausethe patient showed signs of systemic inflammatory response syndrome (SIRS). The general condition of thepatient gradually improved, and the patient was discharged from hospital on November, 2001.
