General Outlines of JPN Guideline for the Management of Acute Pancreatitis

Special Reference to the Continuous Regional Arterial Infusion Therapy with a Protease Inhibitor and Antibiotic

Abstract

The therapeutic management of severe acute pancreatitis was generally introduced according to the JPN Guideline for the management of Acute Pancreatitis. Continuous Regional Arterial Infusion of an antibiotics and protease inhibitor (CRAI) has been frequently employed in Japan, and the aforementioned guideline now gives CRAI the status of a therapeutic option. CRAI has been thought of as to be a potent therapy because of the nature of the treatment, in which highly concentrated antibiotics and protease inhibitor are delivered by way of local intra-arterial infusion. However, it seems warranted that more evidence on the clinical usefulness of CRAI should be acquired, before it can be recognized as the treatment of choice.