Intercalation Compounds of Layered Titanium Phosphate for Drug Delivery Use

Abstract

Layered inorganic material, γ-titanium phosphate (γ-TiP), was applied as a host material for drug delivery use. Hygroscopic diclofenac sodium (DFS) was selected as a model drug to improve its anti-humidity and anti-oxidation. The intercalation was carried out in ethanol solution of DFS. Propylamine was used as the third compound to expand interlayer gallery and/or exfoliate lamellae. The amount of intercalated DFS was almost independent on the concentration of propylamine added. The drug release characteristics was also investigated. The release rate of DFS from the intercalation compound was slower than DFS powder and almost all DFS intercalated was released within 120 min.