The elastic protein connectin/titin in skeletal muscle contraction

Abstract

In a sarcomere, actin and myosin filaments act as the contractile unit. Muscle contraction is produced when actin filament slides relative myosin filament. This mechanism is called the sliding filament and cross-bridge theory. While concentric and isometric contractions are well explained by this theory, passive restoring forces arise in eccentric muscle contractions are not. Here, we described the role of third filament, connectin/titin in eccentric muscle contractions.