Estimation of Occurrence Rate of Drug-induced Interstitial Pneumonia using Accumulated Medical Record Data in a Hospital

Abstract

 Interstitial pneumonia (IP) is one of the serious adverse drug events. IP is mainly diagnosed by chest CT. Chest X-ray, KL-6 and SP-D are useful as adjuncts to the diagnosis. We developed a method that detects the occurrence of IP by using accumulated data in a hospital information system. Furthermore, we devised a method to detect drug-induced IP (DIP) from timing of administration of drug and occurrence or remission of interstitial pneumonia. IP was determined by the report of CT if CT has been done, otherwise it was determined by changing results of Chest X-ray, KL-6 and SP-D. DIP was determined by the pattern of IP before, during and after drug administration. We tried to detect DIP by amiodarone for validation of this method. The number of patients who suffered from amiodarone causing IP was 16(3.9%) including 1 definitive diagnosis (0.2%) and 15 strong doubt (3.6%). Therefore, it can be said that by using this method we could detect the occurrence of DIP from accumulated data in a hospital information system.