Original Article-Technical
Analysis of Dialysate Flow Rate of Continuous Renal Replacement Therapy Database in Sepsis: A Single-center Retrospective Observational Study
2019 Volume 39 Issue 2 Pages 61-72
Details
2019 Volume 39 Issue 2 Pages 61-72
Background:
Several studies on sepsis have shown that increasing the dialysate flow rate of continuous renal replacement therapy (CRRT) does not contribute to a decrease in mortality. The purpose of this study was to develop a CRRT database, analyze the mortality rate of sepsis, and analyze the dialysis practice of CRRT.
Method:
The definition of the purification amount of CRRT in this study was the standard volume group (800 mL/h or less) and the high volume group (801 mL/h or more). The primary end-point was 90-days mortality. A p-value <0.05 was considered statistically significant.
Result:
Among 2,837 patients who were admitted to participating ICUs between January 1, 2014 and December 31, 2017, there were 31 (1.1％) patients who met the inclusion criteria for CRRT-requiring sepsis. The chi-square test showed no significant difference in 90-days mortality between the standard and high volume group (59％ vs. 89％, p=0.24).
Conclusion:
In this study, we analyzed patient mortality rates for CRRT clearance by developing a database of population groups that underwent CRRT for sepsis. The conclusion was that there was no patient increase of mortality rate even if the amount of dialysate flow rate above CRRT’s medical treatment fee was increased.
