Development of the Japanese Version of Pre-eclampsia Ontology

Abstract

　In the previous study, we developed Preeclampsia Ontology (PEO) from research articles of international journals on Preeclampsia (PE). PEO provides wide range of terminology, concepts and their relationships about PE in hierarchical structure and expected to be used for PE-specific knowledge discovery. However, PEO was not able to be applied to secondary use of clinical data and literature in Japanese because PEO was not localized to Japanese. In this study, we localized terminology of PEO from English to Japanese to develop Japanese version of PEO. Localization was performed with a combination of dictionary-based using multiple dictionaries and expert-based localization. The developed Japanese version of PEO provides formal naming of preeclampsia knowledge domain in both Japanese and English. The terminology of the Japanese version of PEO consist mainly of molecules and phenotypes include gene names, chemical compounds, outcomes of pregnancy, complications, laboratory tests and diagnoses. The Japanese version of PEO is expected to apply various medical informatics tasks such as information retrieval and interoperation of clinical data in international cooperation.