超音波内視鏡下穿刺吸引Endoscopic ultrasonography-fine needle aspiration（EUS-FNA）の細胞診検体においてセルブロック法が診断に有用であった2例

西川 詩織; 徳満 貴子; 野口 裕史; 黒木 栄輝; 大野 招伸; 甲斐 眞弘; 佐藤 勇一郎

doi:10.14932/jamt.15-8

Case Reports

Two cases of pancreatic neuroendocrine tumor and gastric gastrointestinal tumor diagnosed by endoscopic ultrasonography fine needle aspiration with cell block procedure

Shiori NISHIKAWA, Takako TOKUMITSU, Hiroshi NOGUCHI, Eiteru KUROKI, Akinobu OHNO, Masahiro KAI, Yuichiro SATO

Author information

Shiori NISHIKAWA
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Takako TOKUMITSU
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Hiroshi NOGUCHI
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Eiteru KUROKI
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Akinobu OHNO
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Masahiro KAI
Department of Surgical Oncology and Regulation of Organ Function, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Yuichiro SATO
Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki

Keywords: EUS-FNA, cytology, cellblock, neuroendocrine tumor, gastrointestinal stromal tumor

JOURNAL FREE ACCESS

2015 Volume 64 Issue 5 Pages 559-563

DOI https://doi.org/10.14932/jamt.15-8

Details

Abstract

Endoscopic ultrasonography fine needle aspiration (EUS-FNA) cytology has proven to be useful for the evaluation of pancreatic tumors or gastric submucosal tumors. In the present study, utilizing the cell block procedure, we examined a diagnostic approach of endoscopic ultrasonography fine needle aspiration (EUS-FNA) cytology in two patients with these lesions. In patient 1, EUS-FNA cytology showed round cells in loose small clumps with focal rosettes or a ribbonlike structure. Immunohistostaining by the cell block procedure revealed the positivity for chromogranin A and synaptophysin in the tumor cells. We diagnosed a neuroendocrine tumor. In patient 2, EUS-FNA cytology showed spindle tumor cells with nuclear palisading. Immunohistostaining by the cell block procedure revealed the positivity for DOG-1, c-kit, and CD34 in the tumor cells. We diagnosed a gastrointestinal stromal tumor. Our findings suggest that EUS-FNA cytology with the cell block procedure offers diagnostic efficacy in patients with pancreatic tumors or gastrointestinal submucosal tumors.

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