2016 Volume 65 Issue 6 Pages 620-628
Dipstick urinalysis is useful and clinically available for the screening of kidney and urological diseases. Since the dipstick method is based on a chemical reaction, it is affected by chemical substances such as drugs that cause false positive or false negative results. In this study, three automatic urine analyzer models (AUTION MAX AX-4060: ARKRAY, Inc.; US-3100R plus: EIKEN Chemical, Inc.; Clinitek Novus: SIEMENS Healthcare Diagnostics, Inc.) were compared in terms of their basic performance and abnormal reaction detection system. In addition, the effect of ascorbic acid on the abnormal reaction detection systems of the three models for false-positive samples was examined. The rates of concordance of results with those of dipstick urinalysis were more than 95% in all three models. In contrast, the detection rate of false-positive samples differed among the three models examined, especially in terms of the effect of ascorbic acid, potentially due to the difference in their detection systems. In conclusion, in the case of routine urinary laboratory examination, the characteristic and/or the basic performance of automatic urine analyzer models need to be considered to avoid pitfalls of abnormal reaction.
