2019 Volume 68 Issue 1 Pages 13-18
The soluble fibrin (SF) monomer and D-dimer are well recognized for their use as predictive markers of thrombosis or fibrinolysis. We measured SF monomer and D-dimer levels to distinguish deep vein thrombosis (DVT). Furthermore, when the SF monomer and D-dimer levels were high, we performed enhanced CT examination. In our examination, the measurement of SF monomer or D-dimer level revealed DVT in 30% of all the patients in our hospital. However, in some patients, we were unable to find DVT, arterial thrombus, or bleeding even when their SF monomer or D-dimer levels were high. In this study, we examined the SF monomer and D-dimer levels in a preoperative patient by end venous laser ablation (EVLA). We examined the relationship of SF monomer and D-dimer levels with venous thrombus by ultrasonography. The patients in which thrombi were detected by ultrasonography or contrast CT, or those with malignant tumor, pneumonia, or diabetes were excluded from this study. We divided the patients into two groups on the basis of varicose vein size determined from ultrasonography images. The varicose vein size of the dilated group was over 8 mm and that of the nondilated group was under 8 mm. The SF monomer level of the dilated group was significantly higher than that of the nondilated group (p < 0.01). The relationship among the size of the varicose vein, the venous reflux flow, and the thrombus size is known. However, it was suspected that the high SF monomer level indicated the presence of not only thrombi but also venous stasis.
