Japanese Journal of Medical Technology
Online ISSN : 2188-5346
Print ISSN : 0915-8669
ISSN-L : 0915-8669
Original Articles
Validation of heterotypic cell-related comments on urinary sediments in our hospital: Relevance of urine screening in urine cytology
Misuzu OURARyuichi TAKAMIZUKaoru HARUYAMANozomi TOYOSHIMAReina TANIGUCHIAkihiro MIMURAYasushi KAWABUCHIKatsuyuki NAGATOYA
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2021 Volume 70 Issue 2 Pages 193-197

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Abstract

In this retrospective study, we evaluated the association between the detection of five types of atypical cells in urine sediments and cytodiagnosis results in our hospital. We identified 876 urine sediment specimens with attached comments concerning the detection of atypical cells. Moreover, 348 of 876 cases whose cytological findings were available were included in this study and classified as the benign group (class I–IIIa cytology reports, 109 cases, 28.8%) and the malignant group (class IIIb–IV cytology reports, 239 cases, 63.2%). Thirty cases with class III cytology reports without a or b were excluded from this study. The validity of the atypical comments on the reports was examined. The occurrence ratios of comments about atypical cells in the benign group were as follows: 40.4% included notes about cell clusters, 58.7% about high N/C ratios, 4.6% about nuclear irregularity, 10.1% about hyperchromasia, and 18.3% about recommendations for further analysis. Comments in the malignant group included detection of cell clusters (23.8%), high N/C ratios (82.8%), nuclear irregularity (12.6%), hyperchromasia (29.3%), and recommendations for further analysis (43.9%). The following were the positive predictive values for the malignant group: 56.4%, presence of cell clusters; 75.6%, high N/C ratios; 85.7%, nuclear irregularity; 86.4%, hyperchromasia; and 84.0%, recommended for further analysis. Conclusively, the presence of multiple comments within a single patient case was associated with an increased positive predictive value in the malignant group, confirming that the identification of the five types of atypical cells is a useful screening technique in malignant urogenital diseases.

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© 2021 Japanese Association of Medical Technologists
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