Analysis of factors affecting the antibody titer obtained after vaccination against the new coronavirus

Abstract

We conducted research on the amount of antibody against the new coronavirus in 56 medical professionals who were vaccinated with the new coronavirus vaccine “COMIRNATY intramuscular injection” manufactured by Pfizer^©. In this study, we measured the antibody titer in all the samples from the subjects using Lumipulse^®G1200 and SARS-CoV-2 S-IgG measuring reagent (IC) (H.U. Frontier Co., Ltd.). Results showed that all the subjects obtained antibody titers that were higher than the cutoff value (1.0 AU/mL). The lowest antibody titer was 10.5 AU/mL, the highest antibody titer was 227.2 AU/mL, and the median was 62.2 AU/mL. We analyzed the factors that affect the antibody titer, focusing on gender, age, BMI, HBV antibody titer, and drinking/smoking habits. We found that the antibody titer was affected only by age, and the other factors did not show statistically significant differences. We suggest that it is possible to induce antibodies to SARS-CoV2 even in a person with a poor immune response to the hepatitis B vaccine. However, further detailed investigation is needed.