2023 Volume 72 Issue 2 Pages 210-215
Urinalysis is a typical non-invasive test and is widely used as a test for preliminary disease diagnosis. Recently, an increasing number of facilities have introduced automatic analyzers to improve the efficiency and speed of urine sedimentation tests. When using it, the detection limit of automatic analyzers should be determined, and urine sediment examination by microscopy should be performed for specimens with unreliable results. The significance of the values was verified by comparing the Atyp.C (atypical cell) values in the fully automated urinary particle analyzer UF-5000 with the cells and their background in urine cytology and urine sediment examination. When the cut-off value was set at 0.5/μL, the sensitivity, specificity and coincidence rates were 64.7%, 90.5% and 88.6%, respectively, for urine cytology class IV or higher as positive. A cut-off of 0.5/μL is considered appropriate when Atyp.C values are used in actual routine examinations. Many of the samples with high Atyp.C values, which deviated from the results of urine cytology, showed cells associated with inflammation, and it was inferred that this was due to the characteristics of Atyp.C value, which reflects cells associated with inflammation, such as cytoplasmic inclusion somatic cells. Specimens with low Atyp.C and deviating from urine cytology results may be due to low numbers of cells present or strong degeneration, making them difficult for the automatic analyzer to recognize. It is possible to catch atypical cells that have been overlooked until now by using Atyp.C, values. This is of great significance because it may lead to the early detection of lesions and contribute to clinical practice.
