2025 Volume 74 Issue 1 Pages 88-93
Diabetes management has made great strides with the advent of safe and convenient diabetes medications. Continuous glucose monitoring is essential for effective glycemic control, and flash glucose monitoring systems (FGMS) such as the Freestyle Libre Pro® (Libre Pro) provide minimally invasive and continuous monitoring capabilities. However, discrepancies in interstitial fluid glucose concentrations between anatomic sites, particularly in the bilateral upper arms, have not yet been fully investigated. The purpose of this study was to compare bilateral upper arm interstitial fluid glucose concentrations using Libre Pro. 14 days of bilateral arm interstitial fluid glucose concentrations were monitored in male subjects aged 20 to 30 years. Differences in bilateral upper arm glucose concentrations were analyzed. Significant differences in interstitial fluid glucose concentrations were observed between the bilateral upper arms, with the dominant arm having lower concentrations. Diurnal variations in glucose concentrations were observed, with lower concentrations at night than during the day. Differences in interstitial fluid glucose concentrations between the bilateral upper arms suggest the possibility of influencing monitoring accuracy and treatment decisions. These results emphasize the need for further research to optimize diabetes treatment strategies. The bilateral brachial differences in interstitial fluid glucose concentrations observed in this study emphasize the importance of anatomic considerations in glucose monitoring and diabetes management.
